| 研究業績 |
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| I. 原著論文(2008年以降)
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| 2018
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| 1 |
Tsubokura M, Nomura S, Yoshida I, Toyoaki SawanoT, Makoto Miyazaki M, Tomita S, Tomoyoshi O, Watanabe M. : Comparison of external doses between radio- contaminated areas and areas with high natural terrestrial background using the individual dosimeter ‘D-shuttle’ 75 months after the Fukushima Daiichi nuclear power plant accident. J. Radiol. Prot. 60: 1-13, 2018. |
| 2015 |
| 1 |
Watanabe M.: The Main Target of Carcinogenesis Is Not DNA. Gan To Kagaku Ryoho. 42(13): 2409-2413, 2015. Review (Japanese) |
| 2 |
Kobashigawa S, Kashino G, Mori H, Watanabe M.: Relief of delayed oxidative stress by ascorbic acid can suppress radiation-induced cellular senescence in mammalian fibroblast cells. Mech Ageing Dev. 146-148: 65-71,2015. |
| 2013 |
| 1 |
Tamari Y, Nawata H, Inoue E, Yoshimura A, Yoshii H, Kashino G, Seki M, Enomoto T, Watanabe M, Tano K. : Protective roles of ascorbic acid in oxidative stress induced by depletion of superoxide dismutase in vertebrate cells.
Free Radic Res. 47(1):: 1-7, 2013. |
| 2 |
Takeshita S, Matsuda N, Kodama S, Suzuki K, Watanabe M.: In vitro thermal effects on embryonic cells of endangered hawksbill turtle Eretmochelys imbricata. Zoolog Sci. 30(12): 1038 - 1043, 2013.
Free Radic Res. 47(1): 1-7, 2013. |
| 3 |
Kashino G, Suzuki K, Kodama S, Watanabe M, Prise KM.: Increased susceptibility to delayed genetic effects of low dose X-irradiation in DNA repair deficient cells. Int J Radiat Biol. 89(4): 295-300, 2013. |
| 4 |
Kashino G, Tamari Y, Kumagai J, Tano K, Watanabe M.: Suppressive effect of ascorbic acid on the mutagenesis induced by the bystander effect through mitochondrial function. Free Radic Res. F 47(6-7) : 474-479, 2013. |
| 2012 |
| 1 |
Suzuki M, Suzuki K, Kodama S, Yamashita S, Watanabe M. : Persistent amplification of DNA damage signal involved in replicative senescence of normal human diploid fibroblasts.
Oxid Med Cell Longev. 2012: Article ID 310534. |
| 2 |
Okada T, Kashino G, Nishiura H, Tano K, Watanabe M. :
Micronuclei formation induced by X-irradiation does not always result from DNA double-strand breaks.
J Radiat Res (Tokyo). 53(1): 93-100, 2012. |
| 3 |
Nishiura H, Kumagai J, Kashino G, Okada T, Tano K, Watanabe M. :
The bystander effect is a novel mechanism of UVA-induced melanogenesis.
Photochemistry and Photobiology. 88(2): 389-397, 2012. |
| 2011 |
| 1 |
Suzuki K, Yamaji H, Kobashigawa S, Kawauchi R, Shima K, Kodama S, Watanabe M : Epigenetic Gene Silencing is a Novel Mechanism Involved in Delayed Manifestation
of Radiation-Induced Genomic Instability in Mammalian Cells.
Radiat Res. 175(4): 416-423, 2011. |
| 2 |
Yuhei Mori , Kenzo Aki, Katsunori Kuge, Shingo Tajima, Natsuko Yamanaka,
Yuichi Kaji, Naoki Yamamoto, Ryoji Nagai , Hanako Yoshii, Norihiko Fujii,
Masami Watanabe, Tadatoshi Kinouchi and Noriko Fujii : UV B-irradiation enhances the racemization and isomerizaiton of aspartyl res
idues and production of Nε-carboxymethyl lysine (CML) in keratin of skin.
J Chromatogr B Analy Technol Biomed Life Sci. 879(29)3303-3309, 2011. |
| 3 |
Nawata H, Kashino G, Tano K, Daino K, Shimada Y, Kugoh H, Oshimura M,
Watanabe M. : Dysregulation of gene expression in the
artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes.
Pros ONE. 6(9): e25319, 2011. |
| 2010 |
| 1 |
Kohzaki M, Nishihara K, Hirota K, Sonoda E, Yoshimura M, Ekino S,
Butler JE, Watanabe M, Halazonetis TD, Takeda S: DNA polymerases nu and theta are required for efficient
immunoglobulin V gene diversification in chicken.J Cell Biol. 189(7):1117-1127, 2010.
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| 2 |
Masunaga SI, Tano K, Nakamura J, Watanabe M, Kashino G, Takahashi A,
Tanaka H, Suzuki M, Ohnishi K, Kimase Y, Lui Y, Ohnishi T, Ono K: Usefulness of hexamethylenetetramine as as adjuvant to
radiation and cisplatin in the treatment of solid tumors: its independency of p53 status. J Radiat Res. 51(1):
27-35, 2010. |
| 3 |
Masunaga SI, Tano K, Nakamura J,Watanabe M, Kashino G, Suzuki M,
Kinashi Y, Ono K: Adverse effect of mild temperature hyperthermia combined with hexamethylenetetramine
in the treatment of solid tumors: compared with its effect combined with tirapazamine.
Exp Ther Med. 1: 169-174, 2010. |
| 4 |
Kashino G, Liu Y, Suzuki M, Masunaga S, Kinashi Y, Ono K, Tano K,
Watanabe M : An alternative mechanism for radioprotection by dimethyl sulfoxide; possible facilitation of DNA
double-strand break repair.
J Radiat Res. 51(6): 733-470, 2010. |
| 5 |
Suzuki K, Kodama S, Watanabe M : Role of Ku80-dependent end-joining
in delayed genomic instability in mammalian cells surviving ionizing radiation.
Mutat Res. 683 (1-2): 29-34, 2010. |
| 6 |
Inoue E, Tano K, Yoshii H, Nakamura J, Tada S, Watanabe M, Seki M,
Enomoto T : SOD1 Is Essential for the Viability of DT40 Cells and Nuclear SOD1 Functions as a Guardian of Genomic DNA.
J Nucleic Acids. 2010 Aug 5: 2010.pii:795946 |
| 7 |
Asagoshi K, Tano K, Chastain PD 2nd, Adachi N, Sonoda E, Kikuchi K,
Koyama H, Nagata K, Kaufman DG, Takeda S, Wilson SH, Watanabe M, Swenberg JA, Nakamura J :
FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells.
: 204-215, 2010.
Mol Cancer Res. 8(2): 204-215, 2010. |
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| 2009 |
| 1 |
Asagoshi K, Tano K, Chastain II PD, Adachi N, Sonoda E, Kikuchi K, Koyama H, Nagata K,
Kaufman DG, Takeda S, Wilson SH, Watanabe M, Swenberg JA, Nakamura J: FEN1 functions in long patch base excision repair under
conditions of oxidative stress in vertebrate cells. Mol Cancer Res.8(2): 204-215, 2010. |
| 2 |
Masunaga S, Tano K, Watanabe M, Kashino G, Suzuki M, Kinashi Y,
Ono K, Nakamura J : Evaluation of the potential of hexamethylene-tetramine as a combined agent with gamma-ray
irradiation and cisplatin treatment in vivo, compared with tirapazamine. British J Radiol. 82(977): 392-400 2009. |
| 3 |
Kashino G, Kondoh T, Nariyama N, Umetani K, Ohigashi T, Shinohara K,
Kurihara A, Fukumoto M, Tanaka H, Maruhashi A, Suzuki S, Kinashi Y, Liu Yong, Masunaga S, Watanabe M, Ono K :
Induction of DNA double-strand breaks and cellular migration through bystander effects in cells irradiated with
the slit-type microplanar beam of the SPring-8 synchrotron. Intern J Radiat Oncol Biol Phys. 74(1): 229-236, 2009. |
| 4 |
Masunaga S, Kono K, Nakamura J, Tano K, Yoshida Y, Watanabe M, Kashino G, Suzuki M,
Kinashi Y, and Ono K : Usefulness of hexamethylenetetramine in combination with chemotherapy using free and pegylated liposomal
doxorubicin in vivo, referring to the effect on quiescent cells. Oncology Report 21: 1307-1312, 2009 |
| 5 |
Toyokuni H, Maruo A, Suzuki K, Watanabe M : The contribution of
radiation-induced large deletion of the genome to chromosomal instability. Radiat Res 171: 198-203, 2009.
|
| 6 |
Yoshii H, Watanabe M : Intervention of oxygen-control ability to
radiation sensitivity, cell aging and cell transformation. J Radiat Res (Tokyo) 50: 127-137, 2009. |
| 7 |
Yoshikawa T, Kashino G, Ono K, Watanabe M : Phosphorylated H2AX foci in
tumor cells have no correlation with their radiation sensitivities. J Radiat Res(Tokyo) 50: 151-160, 2009. |
| 8 |
Suzuki K, Kodama S, Watanabe M: Role of Ku80-dependent end-joining in delayed
genomic instability in mammalian cells surviving ionizing radiation. Mutat Res. 683(1-2): 29-34, 2009. |
| 9 |
Suzuki K, Kashino G, Kodama S, Watanabe M: Long-term persistence of X-ray-induced
genomic instability in quiescent normal human diploid cells. Mutat Res. 671(1-2): 33-39, 2009. |
| 10 |
Ariyoshi K, Suzuki K, Goto M, Oshimura , Ishizaki K, Watanabe M, Kodama S:
Introduction of a normal human chromosome 8 corrects abnormal phenotype of Werner syndrome cells immortalized by expressing
an hTERT gene. J Radiat Res. 50(3): 253-259, 2009. |
| 11 |
Pachkowski BF, Tano K, Afonin V, Elder RH, Takeda S, Watanabe M, Swenberg JA,
Nakamura J: Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the
PARP-1-proficient cells exposed to MMS. Mutat Res. 671(1-2): 93-99, 2009. |
| 12 |
Takada S, Inoue E, Tano K, Yoshii H, Abe T, Yoshimura A, Akita M, Tada S,
Watanabe M, Seki M, Enomoto T: Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD2.
Biochem Biophys Res Commun. 379(2): 233-238, 2009. |
| 13 |
Watanabe M, Yoshii H: Target of radiation carcinogenesis is protein: Becoming triploid is proximate cause
of cell transformation. in "Radiation Health Risk Sciences", eds. Nakashima M, Takamura N, Tsukasaki K,
Nagayama Y, Yamashita S, pp. 212-215, Springer, 2009. |
| 14 |
Hori M, Suzuki K, Udono MU, Yamauchi M, Mine M, Watanabe M, Kondo S, Hozumi Y:
Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells, cell growth suppression by p53
expression and the suppression mechanism. Arch Dermatol Res. 301(9): 631-646, 2009. |
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| 2008 |
| 1 |
Hori M, Suzuki K, Udono MU, Yamauchi M, Mine M, Watanabe M,
Kondo S, Hozumi Y : Establishment of ponasterone A-inducible the wild-type p53 protein-expressing clones from
HSC-1 cells, cell growth suppression by p53 expression and the suppression mechanism. Arch Dermatol Res. 301(9): 631-646 , 2008. |
| 2 |
Hamamoto T, Suzuki K, Yamauchi M, Kodama S, Sasaki H, Watanabe M :
p53 status-dependent sensitization of human tumour cells to hyperthermia by plant flavonol. Int J Hyperthermia 24 :
415-425, 2008. |
| 3 |
Yamauchi M, Oka Y, Yamamoto M, Niimura K, Uchida M,
Kodama S, Watanabe M, Sekine I, Yamashita S, Suzuki K：
Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1
checkpoint signaling. DNA Repair (Amst) 7 : 405-417, 2008. |
| 4 |
Harada T, Kashino G, Suzuki K, Matsuda N, Kodama S, Watanabe M :
Different involvement of radical species
in irradiated and bystander cells. Int J Radiat Biol 84: 809-814, 2008. |
| 5 |
Takada S, Inoue E, Tano K, Yoshii H, Abe T, Yoshimura A,
Akita M, Tada S, Watanabe M, Seki M, Enomoto T: Generation and characterization of cells that can be
conditionally depleted of mitochondrial SOD2. Biochem Biophys Res Commun 379 : 233-238, 2008.
|
| II. 特許 |
| 1 |
小林信之、渡邉正己：微生物による環境モニター技術、特願2005-248816号 |
| 2 |
渡邉正己、児玉靖司、鈴木啓司、竹下哲史：テロメレース抑制能を有する微生物とテロメレース抑制剤、特願2004-060625号 |
| 3 |
中島 琢自、加藤 陽子、竹下 哲史、松田 尚樹、児玉 靖司、渡邉 正己：石油類分解微生物および石油類の処理方法、特願2004-78812号 |
| 4 |
中島 琢自、加藤 陽子、竹下 哲史、松田 尚樹、児玉 靖司、渡邉 正己：農薬活性成分としてプロジギオシン類を有効成分として含有するこ とを特徴とする光分解性農薬組成、特願2004-93597号 |
| 5 |
中島琢自、加藤陽子、児玉靖司、渡邉正己：プロジギオシン類色素の製造方法およびそれに使用する新規な微生物、特願2004-78807号 |
| 6 |
中島琢自、加藤陽子、竹下哲史、松田尚樹、児玉靖司、渡邉正己：微生物分離法、特願2004-040349号 |
| 7 |
渡邉正己、児玉靖司、鈴木啓司、竹下哲史：メラニン生成抑制能を有する微生物とメラニン生成抑制剤、特願2003-008683号 |
| 8 |
渡邉正己、竹下哲史、松田和子：赤潮防除剤、特願2000-248816号 |
| 9 |
村松毅、渡邉正己、林田眞二郎、福田久孝：アルギン酸分解酵素、特許願2000-97450号 |
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msm@rbnet.jpまでお知らせください。
|
May 1, 2009, Ver.5, by Masami Watanabe, info-rb@rri.kyoto-u.ac.jp
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